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KMID : 0359319950350030471
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Korean Journal of Veterinary Research
1995 Volume.35 No. 3 p.471 ~ p.480
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Pharmacokinetics of ciprofloxacin in chickens
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김재학/Kim, Jae Hak
이재진/조명행/강환구/손성완/이항/한명국/Lee, Jae Jin/Cho, Myung Haing/Kang, Hwan Goo/Son, Seong Wan/Lee, Hang/Han, Myung Guk
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Abstract
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The purpose of this experiment was to develop a simple and reliable HPLC method for the detection of ciprofloxacin in chicken serum and to provide a basic data on pharmacokinetic parameters after oral and intramuscular administration. The results obtained were as follows:
1. 0.2% meta-phosphoric acid: acetonitrile(7:3, v/v) solution had a high and regular recovery rates and was selected as an extraction solution.
2. The recovery rates of ciprofloxacin were 83-97% with the selected solution in chicken serum and the detection limit was 50ng/㎖ in serum.
3. Ka(abosorption rate constant) were 3.652 1/h in fasted group and 0.880 1/h in non-fasted group, and Ke (elimination rate constant) were 0.061 1/h and 0.133 1/h, respectively.
4. The highest concentration in serum after intramuscular injection was 840ng/㎖ within 15-30min and 160-324ng/㎖ in 1.1-3.2 hours after oral administration.
5. The time course of blood concentration fits well into a 2 compartment model.
6. On oral administration of ciprofloxacin with feed, ciprofloxacin was absorbed more slowly and the amount of absorbed was smaller than that of in fasted chickens.
7. Blood concentration of ciprofloxacin increased in a dose-dependent manner after intramusclular and oral administraiton.
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